Osteogenesis Imperfecta is a genetic skeletal disease commonly known as the "brittle bone". In this disease the bones break easily and often without any obvious reason. This happens due to abnormality of proteins in the bones.

Osteogenesis Imperfecta means imperfect bone formation. Those who are suffering from this condition get their bones break very easily. Compound fractures are frequent, and in some severe cases, it develops in child before birth. Few children born under this disease die soon after birth. Milder cases may involve only a few fractures over a person's lifetime.

Osteogenesis Imperfecta is not confined to age, sex or region. In every ten thousand people one (1) person can be found in this condition. In United States approximately fifty thousand or more people are affected from Osteogenesis Imperfecta.

The name "Osteogenesis Imperfecta" dates to at least 1895 and has been the usual medical term in the twentieth century to present. Other names people use for Osteogenesis Imperfecta are ...

• Brittle bone disease
• Fragilitas ossium
• OI
• Vrolik disease
• Osteoporosis

OI is a genetic disease, usually the faulty gene is inherited from one of the parent. The defected gene is responsible for making collage, a protein that helps make bones strong.

Rarely someone develop OI when neither parent carried the faulty gene. This is called a spontaneous mutation, a random gene change.

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